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KMID : 0545120120220030326
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Journal of Microbiology and Biotechnology
2012 Volume.22 No. 3 p.326 ~ p.330
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Elucidation of Antifungal Metabolites Produced by Pseudomonas aurantiaca IB5-10 with Broad-Spectrum Antifungal Activity
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Park Gwee-Kyo
Lim Jong-Hui
Kim Sang-Dal
Shim Sang-Hee
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Abstract
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Antifungal metabolites were isolated from a culture of Pseudomonas aurantiaca IB5-10. Chemical structures of the metabolites were elucidated as phenazine-1-carboxylic acid (PCA; 1), 2-hydroxyphenazine (2-OH-PHZ; 2), and cyclo-(L-Pro-L-Val; 3), respectively, based on spectroscopic methods. Among them, 3 was isolated for the first time from this strain. The antifungal activities of 1-3 were evaluated against a variety of plant pathogens. To the best of our knowledge, the antifungal activities of 3 against plant fungal pathogens have been evaluated for the first time in this work. PCA (1) showed the most potent antifungal activities against Phytophthora capsici, Rhizoctonia solani AG-1(IA), and Pythium ultimum with MICs (μg/ml) of less than 1.0, 1.3, and 2.0, respectively. On the other hand, 2-OH-PHZ (2) showed potent antifungal activity against R. solani AG-1(IA) with the MIC (μg/ml) of 2.0, whereas it showed moderate antifungal activity against P. ultimum with the MIC (μg/ml) of 50.0. In addition, 3 showed antifungal activity against only R. solani AG- 1(IA).
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KEYWORD
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Pseudomonas aurantiaca, antifungal activities, Phenazine-1-carboxylic acid (PCA), 2-Hydroxyphenazine (2-OH-PHZ), Cyclo-(L-Pro-L-Val)
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